What is supported by the evidence?
Established cardiovascular risk equations, including Framingham models, estimate future cardiovascular risk using combinations of risk factors. CDC researchers have translated a non-laboratory Framingham estimate into predicted heart age. Read the CDC study.
BMI-based and cholesterol-based routes
HeartAGE uses a BMI-based calculation when cholesterol is unavailable and a cholesterol-based calculation when suitable cholesterol results are available. Each approach has its own inputs, intended population, and limitations. Reports should identify the method used; switching methods can change the result even without a change in health.
What does a heart-age result mean?
It expresses an estimated risk relative to a reference risk profile. It is not a direct measurement of the heart’s biological age, a diagnosis of cardiovascular disease, or a substitute for a clinical evaluation.
What does “validated” apply to?
Validation evidence belongs to the specific risk equation, population, inputs, and outcomes studied. That evidence does not automatically validate a branded report, a software implementation, or claims that a workplace event improves outcomes. The calculation must faithfully implement the model and be used within its supported scope.
Screening should connect to action
The clinical plan should define eligibility, measurement quality, confirmation of abnormal results, and referral or follow-up. Aggregate risk reporting requires consistent methods and attention to changes in participants. A change in estimated risk alone does not prove that the program caused better health or lower healthcare spending.